v0.43.2

0.43.2 (2026-05-07)

⚠ BREAKING CHANGES

• add experimental option to predict compound effect of multiple variants on the same transcript, allow building txdb from gff3+fasta (#972)

Features

• add experimental option to predict compound effect of multiple variants on the same transcript, allow building txdb from gff3+fasta (#972) (e377c4e)
• add options to include reference/alternative cDNA and protein sequences in output (#966) (ec87cb0)
• Add python bindings via pyO3 (#959) (b2450be)

Bug Fixes

• hide server functionality behind feature gate (enabled by default) (#964) (0031153)
• include polars and pyarrow in mehari-python dependencies (#962) (23b75c4)
• pick mode first and length picking (#993) (e63b7b0)

Miscellaneous Chores

• bump version for annonars update (1e625f9)
• bump version for jemalloc default feature (517e1d3)
• Release-As: 0.43.2 (e170371)

v0.42.1

0.42.1 (2026-05-06)

Bug Fixes

• pick mode first and length picking (#993) (e63b7b0)

mehari: v0.43.2

0.43.2 (2026-05-07)

⚠ BREAKING CHANGES

• add experimental option to predict compound effect of multiple variants on the same transcript, allow building txdb from gff3+fasta (#972)

Features

• add experimental option to predict compound effect of multiple variants on the same transcript, allow building txdb from gff3+fasta (#972) (e377c4e)
• add options to include reference/alternative cDNA and protein sequences in output (#966) (ec87cb0)
• Add python bindings via pyO3 (#959) (b2450be)
• allow db subsetting by region (#988) (09aa020)

Bug Fixes

• hide server functionality behind feature gate (enabled by default) (#964) (0031153)
• pick mode first and length picking (#993) (e63b7b0)
• use with_added_extension (#989) (0dd76f9)

Miscellaneous Chores

• bump version for annonars update (1e625f9)
• bump version for jemalloc default feature (517e1d3)
• Release-As: 0.43.2 (e170371)

chore: baseline mehari 0.43.0

Establishing release-please baseline

chore: baseline mehari-python 0.43.0

Establishing release-please baseline

v0.42.0

0.42.0 (2026-04-14)

⚠ BREAKING CHANGES

• add experimental option to predict compound effect of multiple variants on the same transcript, allow building txdb from gff3+fasta (#972)
• allow arbitrary assemblies; this impacts the transcript database protobuf definitions, though we tried keeping them backwards compatible. This also impacts the server REST api.
• refactor annotate seqvars cli (e.g., --input and --output and introduce --output-format etc, allow stdin/stdout)

Features

• add experimental option to predict compound effect of multiple variants on the same transcript, allow building txdb from gff3+fasta (#972) (e377c4e)
• add options to include reference/alternative cDNA and protein sequences in output (#966) (ec87cb0)

v0.41.2

0.41.2 (2026-03-22)

Bug Fixes

• hide server functionality behind feature gate (enabled by default) (#964) (0031153)

v0.41.1

0.41.1 (2026-03-22)

Bug Fixes

• include polars and pyarrow in mehari-python dependencies (#962) (23b75c4)

v0.41.0

0.41.0 (2026-03-21)

Features

• Add python bindings via pyO3 (#959) (b2450be)

v0.40.0

0.40.0 (2026-03-20)

Features

• introduce cli options to disable variant hgvs normalization (#918) (5117d10)
• update hgvs-rs to 0.20.0 (#946) (53071e0)
• vep compatibility mode, additional annotation terms, refactoring (#924) (d314765)

Bug Fixes

• provider.get_seq_part without reference available (#947) (7d882bd)
• clinvar tx acc in db check (#919) (b79e5c3)