diff --git a/tea_test.go b/tea_test.go
index 8d81c77b08..6771bac411 100644
--- a/tea_test.go
+++ b/tea_test.go
@@ -6,6 +6,7 @@ import (
 	"errors"
 	"fmt"
 	"io"
+	"os"
 	"strings"
 	"sync"
 	"sync/atomic"
@@ -30,10 +31,16 @@ type testModel struct {
 	counter  atomic.Value
 }
 
+type quitModel struct{}
+
 func (m *testModel) Init() Cmd {
 	return nil
 }
 
+func (quitModel) Init() Cmd {
+	return Quit
+}
+
 func (m *testModel) Update(msg Msg) (Model, Cmd) {
 	switch msg := msg.(type) {
 	case ctxImplodeMsg:
@@ -66,6 +73,14 @@ func (m *testModel) View() View {
 	return NewView("success")
 }
 
+func (quitModel) Update(msg Msg) (Model, Cmd) {
+	return quitModel{}, nil
+}
+
+func (quitModel) View() View {
+	return NewView("")
+}
+
 func TestTeaModel(t *testing.T) {
 	t.Parallel()
 	var buf bytes.Buffer
@@ -89,6 +104,27 @@ func TestTeaModel(t *testing.T) {
 	}
 }
 
+func TestTeaProgramRunsWithDevNullInput(t *testing.T) {
+	t.Parallel()
+
+	devNull, err := os.Open(os.DevNull)
+	if err != nil {
+		t.Fatal(err)
+	}
+	defer devNull.Close()
+
+	p := NewProgram(
+		quitModel{},
+		WithInput(devNull),
+		WithOutput(io.Discard),
+		WithoutSignals(),
+	)
+
+	if _, err := p.Run(); err != nil {
+		t.Fatalf("expected /dev/null input to be accepted, got %v", err)
+	}
+}
+
 func TestTeaQuit(t *testing.T) {
 	t.Parallel()
 	var buf bytes.Buffer
diff --git a/tty.go b/tty.go
index 12b86493b3..6148dadd0e 100644
--- a/tty.go
+++ b/tty.go
@@ -2,7 +2,9 @@ package tea
 
 import (
 	"fmt"
+	"io"
 	"os"
+	"strings"
 	"time"
 
 	uv "github.com/charmbracelet/ultraviolet"
@@ -52,6 +54,33 @@ func (p *Program) restoreInput() error {
 	return nil
 }
 
+type fallbackInputReader struct {
+	io.Reader
+}
+
+func shouldRetryCancelReaderWithoutFD(input io.Reader, err error) bool {
+	if err == nil || !strings.Contains(err.Error(), "add reader to epoll interest list") {
+		return false
+	}
+
+	file, ok := input.(*os.File)
+	if !ok || term.IsTerminal(file.Fd()) {
+		return false
+	}
+
+	info, statErr := file.Stat()
+	if statErr != nil {
+		return false
+	}
+
+	devNullInfo, statErr := os.Stat(os.DevNull)
+	if statErr != nil {
+		return false
+	}
+
+	return os.SameFile(info, devNullInfo)
+}
+
 // initInputReader (re)commences reading inputs.
 func (p *Program) initInputReader(cancel bool) error {
 	if cancel && p.cancelReader != nil {
@@ -67,6 +96,9 @@ func (p *Program) initInputReader(cancel bool) error {
 
 	var err error
 	p.cancelReader, err = uv.NewCancelReader(p.input)
+	if shouldRetryCancelReaderWithoutFD(p.input, err) {
+		p.cancelReader, err = uv.NewCancelReader(fallbackInputReader{Reader: p.input})
+	}
 	if err != nil {
 		return fmt.Errorf("bubbletea: could not create cancelable reader: %w", err)
 	}